Afdura 10 mg/0.5 mg 10 Tablets

Prescription status:

Prescription required

Manufacturer Name: Sun Pharmaceutical Industries Ltd 

Drug classification:

Selective alpha-adrenoceptor blocking agent, Alpha reductase inhibitors (synthetic 4-azasteroid)

What is this used for

• Benign Prostatic Hyperplasia

When to not take this medicine:

• Hypersensitivity/Known Allergy to this medicine combination
• Orthostatic Hypotension (low blood pressure during standing up from sitting or laying down position)
• Liver dysfunction

How should I take the medicine:

Take this medicine with an adequate amount of water as directed by the physician. Do not take this medicine in small or larger amounts than recommended.

How this medicine works:

This medicine helps in the treatment and prevention of benign prostatic hyperplasia (enlargement of the prostate gland in men).

Side effects

• Cough (unknown)
• Runny Nose (unknown)
• Chest pain (unknown)
• Dizziness (unknown)
• Headache (unknown)
• Body pain (unknown)
• Decreased interest in sexual intercourse (unknown)
• Abnormal ejaculation (unknown)
• Sleeping disturbances (unknown)
• Fever with chills (unknown)
• Nausea and Vomiting (unknown)

Pregnancy warning: 

NOT APPLICABLE as this medicine is mostly used for the treatment in males.

Lactation warning: 

NOT APPLICABLE as this medicine is mostly used for the treatment in males.

Renal dose adjustments:

Care must be taken for individuals with kidney disease while taking this medicine. Please discuss appropriate dose adjustments with your doctor. Your doctor may also prescribe a suitable alternative based on creatinine clearance values

Hepatic dose adjustments:

Care must be taken for individuals with liver disease while taking this medicine. Please discuss appropriate dose adjustments with your doctor. Your doctor may also prescribe a suitable alternative.

Drug interactions:

• Atazanavir-Major

Inform your doctor about the use of either medicine. When these medicines are taken together, it may result in an increase in the serum levels of this medicine and may cause blood pressure to drop extensively and heart rate to increase especially during the rising position from sitting or lying down. Inform your doctor if you experience any unusual signs and symptoms like nasal congestion, dizziness, fainting, flushing, heart palpitation, headache, lightheadedness, etc. Appropriate dose adjustments may be done, or suitable alternate medicine may be considered based on the condition. 

• Clarithromycin-Major

Inform your doctor about the use of either medicine. When these medicines are taken together, it may result in an increase in the serum levels of this medicine and may cause blood pressure to drop extensively and heart rate to increase especially during the rising position from sitting or lying down. Inform your doctor if you experience any unusual signs and symptoms like nasal congestion, dizziness, fainting, flushing, heart palpitation, headache, lightheadedness, etc. Appropriate dose adjustments may be done, or suitable alternate medicine may be considered based on the condition. 

• Nelfinavir-Major

Inform your doctor about the use of either medicine. When these medicines are taken together, it may result in an increase in the serum levels of this medicine and may cause blood pressure to drop extensively and heart rate to increase especially during the rising position from sitting or lying down. Inform your doctor if you experience any unusual signs and symptoms like nasal congestion, dizziness, fainting, flushing, heart palpitation, headache, lightheadedness, etc. Appropriate dose adjustments may be done, or suitable alternate medicine may be considered based on the condition. 

• Posaconazole-Major

Inform your doctor about the use of either medicine. When these medicines are taken together, it may result in an increase in the serum levels of this medicine and may cause blood pressure to drop extensively and heart rate to increase especially during the rising position from sitting or lying down. Inform your doctor if you experience any unusual signs and symptoms like nasal congestion, dizziness, fainting, flushing, heart palpitation, headache, lightheadedness, etc. Appropriate dose adjustments may be done, or suitable alternate medicine may be considered based on the condition. 

• Indinavir-Major

Inform your doctor about the use of either medicine. When these medicines are taken together, it may result in an increase in the serum levels of this medicine and may cause blood pressure to drop extensively and heart rate to increase especially during the rising position from sitting or lying down. Inform your doctor if you experience any unusual signs and symptoms like nasal congestion, dizziness, fainting, flushing, heart palpitation, headache, lightheadedness, etc. Appropriate dose adjustments may be done, or suitable alternate medicine may be considered based on the condition. 

Alcohol interactions:

Consumption of alcohol is not recommended while taking this medicine as it may cause interactions and lead to serious adverse effects and may worsen the health condition.

Food interactions:

N/A

Expert Advice:

1. This medicine can be taken with or without food. Do not chew or crush the tablet. Take it as a whole.
2. Since safety and efficacy are not established clinically, this medicine is not recommended to use in children as well as infants.
3. This medicine is not recommended to use for the treatment or prevention of hypertension.
4. The patients who are taking this medicine are not recommended to donate blood at least from the date of the last dose till 6 months to prevent pregnant women to receive this medicine through blood transfusion.
5. Inform any side effects experienced immediately to the doctor.

Missed dose instructions:

Take this medicine as soon as you remember. However, if it is almost time for your next dose skip the dose and go back to your regular dosing schedule. Do not double dose to make up for the missed dose. 

Overdose Instructions:

Seek emergency treatment or contact your physician in case if you experience any unusual signs and symptoms during the treatment with this medicine.

Storage Instructions:

1. Store this medicine in a cool and dry place away from moisture. 
2. Keep the medicine away from the reach of children

References:

1. Drugs H. Alfuzosin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2020 [cited 28 October 2020]. Available from: https://medlineplus.gov/druginfo/meds/a604002.html

2. Alfuzosin | DrugBank Online [Internet]. Go.drugbank.com. 2020 [cited 28 October 2020]. Available from: https://go.drugbank.com/drugs/DB00346

3. Dutasteride 0.5 mg soft capsules - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2020 [cited 28 October 2020]. Available from: https://www.medicines.org.uk/emc/product/8917/smpc#gref

4. Dutasteride [Internet]. Pubchem.ncbi.nlm.nih.gov. 2020 [cited 28 October 2020]. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Dutasteride

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Keep away from direct sunlight

Store in a dry place