BIDIN LS 0.1 Percent Eye drops 5 ml

Prescription status:

Prescription required 

Manufacturer Name: 

Ajanta Pharma Limited

Drug classification: Beta-

Alpha-adrenergic agonists

What is this used for:

• Intraocular Hypotension
• Glaucoma

When to not take this medicine:

• Hypersensitivity/ allergy to this medicine or ingredients present along with it
• Bradycardia (slow heartbeat)
• Sick sinus syndrome 
• Bronchial asthma or a history of bronchial asthma
• Severe chronic obstructive pulmonary disease (COPD)

How should I take the medicine:

These drops are to be instilled into the eyes twice a day. Follow the instructions provided by the doctor carefully.

How this medicine works:

This medicine combination by reducing the internal pressure of the eyes and Improving the drainage of intraocular fluid. 

Side effects

• Eye irritation(less common)
• Allergic conjunctivitis (Common)
• Erosion of cornea (Less common)
• Eye pruritus (common)
• Burning or stinging sensation of the eyes (Common)
• Headache (Less common)
• Hypertension (Less common)
• Oral dryness (Less common)
• Somnolence (Less common)
• Visual disturbances(Less common)

Pregnancy warning: Category B

Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. 

Lactation warning:

Use of this medicine is not recommended for lactating and breastfeeding mothers unless absolutely necessary. Inform your doctor about the use of this medicine. All the risks and benefits should be discussed with the doctor before taking this medicine.

Renal dose adjustments: 

Care must be taken for individuals with kidney disease while taking this medicine. Please discuss appropriate dose adjustments with your doctor. Your doctor may also prescribe a suitable alternative on the basis of creatinine clearance values.

Hepatic dose adjustments:

Care must be taken for individuals with liver disease while taking this medicine. Please discuss appropriate dose adjustments with your doctor. Your doctor may also prescribe a suitable alternative.

Drug interactions:

• Amiodarone - Unknown

Inform your doctor about the use of either medicines. Care must be taken when these medicines are used together since they may cause serious adverse reactions like low blood pressure, dizziness, confusion, irregular heartbeat, etc. Suitable alternatives may be considered based on the condition of the patient.

• Adrenaline - Major

Inform your doctor about the use of either medicines. Care must be taken when these medicines are used together since they may cause adverse reactions like change in intraocular pressure, visual disturbances, blurred vision, mydriasis, etc. Suitable alternatives may be considered based on the condition of the patient.

• Reserpine- Moderate

Combining these medications may cause the occurrence of severe hypotension and the patient may experience symptoms like syncope, dizziness, blurred vision, incoordination, nausea, vomiting, Vertigo, etc. It is recommended to then inform the doctor on priority. Appropriate dose adjustments may be done, or suitable alternate medicine may be considered based on the condition.

• Diltiazem -Major

Inform your doctor about the use of either medicines. Care must be taken when these medicines are used together since they may cause adverse reactions like arrhythmias, irregular heartbeat, hypotension, bradycardia, vertigo, blurred vision, mydriasis, etc. Suitable alternatives may be considered based on the condition of the patient.

• Verapamil- Major

Inform your doctor about the use of either medicines. Care must be taken when these medicines are used together since they may cause adverse reactions like arrhythmias, irregular heartbeat, hypotension, bradycardia, vertigo, blurred vision, mydriasis, etc. Suitable alternatives may be considered based on the condition of the patient.

Alcohol interactions:

Consumption of alcohol is not recommended while receiving/taking this medicine as it may cause interactions and lead to serious adverse effects and may worsen the health condition.

Food interactions: N/A.

Expert Advice: 

1. For Ophthalmic Use only use only
2. It is recommended to remove contact lenses if being used before administering this medicine.
3. If you experience a burning sensation of blurred vision while using this medicine it is recommended to inform your doctor.
4. Inform your doctor if you have undergone any recent surgeries like dental procedures, Eye surgery, etc.
5. Inform your doctor if you had any recent eye injuries.

Usage Advice:

1. Do not touch the tip of the applicator (dropper)
2. Keep the lid of the applicator closed at all times
3. Discard the unused medicine safely after use.

Missed dose instructions:

Apply this medicine as soon as you remember. However, if it is almost time for your next dose skip the dose and go back to your regular dosing schedule. Do not double dose to make up for the missed dose.

Overdose Instructions:

Seek emergency treatment or contact your physician in case if you experience any unusual signs and symptoms during the treatment with this medicine.

Storage Instructions:

• Store in a cool and dry place.
• Do not touch the tip of the applicator (dropper)
• Keep away from the reach of children. 

References:

1. DailyMed - ALPHAGAN P- brimonidine tartrate solution/ drops [Internet]. Dailymed.nlm.nih.gov. 2020 [cited 10 December 2020]. Available from: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=264c4494-c225-486f-888a-caaf36be46b3#:~:text=patients%20with%20...-,ALPHAGAN%C2%AE%20P%20(brimonidine%20tartrate%20ophthalmic%20solution)%200.1%25%20or,angle%20glaucoma%20or%20ocular%20hypertension.
2. Drugs H. Brimonidine Ophthalmic: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2020 [cited 10 December 2020]. Available from: https://medlineplus.gov/druginfo/meds/a601232.html

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Keep away from direct sunlight

Store in a dry place