Buxoric 40 mg 10 Tablets

Prescription status:

Prescription required

Manufacturer Name:

Macleods Pharmaceuticals Pvt Ltd

Drug classification:

Xanthine Oxidase inhibitor, Anti-Gout agents

What is this used for:

• Gout 
• Hyperurecemia

When to not take this medicine:

• Hypersensitivity or allergy towards Febuxostat
• Cardiovascular diseases

How should i take the medicine:

Take this medicine with an adequate amount of water as directed by the physician. Do not take this medicine in small or larger amounts than recommended.

How this medicine works:

This medicine works by decreasing the production of uric acid within the body

Side effects

• Joint Pain Muscle aches(Common)
• Nausea(Common)
• Stomach pain(Common)
• Rash(Less common)
• Inaccurate liver function test results (Less common)
• Flareup of gout (Less common)
• Kidney function abnormality(Less common)
• Vomiting(Less common)
• Blood dyscrasias(Less common)
• Bronchospasm(Less common)

Pregnancy warning: Category C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Lactation warning:

Use of this medicine is not recommended for lactating and breastfeeding mothers unless necessary. Inform your doctor about the use of this medicine. All the risks and benefits should be discussed with the doctor before taking this medicine.

Renal dose adjustments:

Care must be taken for individuals with kidney disease while taking this medicine. Please discuss appropriate dose adjustments with your doctor. Your doctor may also prescribe a suitable alternative based on creatinine clearance values.

Hepatic dose adjustments:

Care must be taken for individuals with liver disease while taking this medicine. Please discuss appropriate dose adjustments with your doctor. Your doctor may also prescribe a suitable alternative.

Drug interactions:

• Azathioprine- Major

Inform your doctor about the use of either medicine. When these medicines are taken together it may cause changes in the absorption of the medicine and may cause adverse effects like toxicity of bone marrow, blood disorders, infections, etc. Inform your doctor on priority. Appropriate dose adjustments or suitable alternatives may be considered based on your condition.

• Captopril- Major

Inform your doctor about the use of either medicine. When these medicines are taken together it may cause changes in the absorption of the medicine and may cause severe allergic reactions like steven- johnsons syndrome, skin rashes or other severe allergic reactions, etc. Inform your doctor on priority. Appropriate dose adjustments or suitable alternatives may be considered based on your condition.

• Pexidartinib- Major

Inform your doctor about the use of either medicine. When these medicines are taken together it may cause an increase in the toxicity of the medicine and may cause liver damage, hepatotoxicity, etc. Inform your doctor on priority. Appropriate dose adjustments or suitable alternatives may be considered based on your condition.

• Theophylline- Major

Inform your doctor about the use of either medicine. When these medicines are taken together it may cause an increase in the toxicity of the medicine and may cause side effects. Inform your doctor on priority. Appropriate dose adjustments or suitable alternatives may be considered based on your condition.

• Warfarin- Major

Inform your doctor about the use of either medicine. When these medicines are taken together it may cause an increase in the toxicity of the medicine and may cause liver damage, hepatotoxicity, etc. Inform your doctor on priority. Appropriate dose adjustments or suitable alternatives may be considered based on your condition.

• Aluminum hydroxide- Moderate

Inform your doctor about the use of either medicine. When these medicines are taken together aluminum hydroxide decreases levels of febuxostat by inhibition of GI absorption. Inform your doctor on priority. Appropriate dose adjustments or suitable alternatives may be considered based on your condition.

• Amoxicillin- Moderate

Inform your doctor about the use of either medicine. When these medicines are taken together it may cause an increase in the toxicity of the medicine and may cause liver damage, hepatotoxicity, etc. Inform your doctor on priority. Appropriate dose adjustments or suitable alternatives may be considered based on your condition.

• Calcium carbonate- Moderate

Inform your doctor about the use of either medicine. When these medicines are taken together calcium carbonate decreases levels of febuxostat by inhibition of GI absorption. Inform your doctor on priority. Appropriate dose adjustments or suitable alternatives may be considered based on your condition.

• Cyclophosphamide- Moderate

Inform your doctor about the use of either medicine. When these medicines are taken together it may cause an increase in the toxicity of the medicine and may cause liver damage, hepatotoxicity, etc. Inform your doctor on priority. Appropriate dose adjustments or suitable alternatives may be considered based on your condition.

Alcohol interactions:

Consumption of alcohol is not recommended while receiving/taking this medicine as it may cause interactions and lead to serious adverse effects and may worsen the health condition.

Food interactions:

N/A

Expert Advice:

1. These tablets can be taken with food or without food. Do not crush, chew, or break the tablet. Swallow it whole.
2. This medicine is not to be taken along with medications like Azathioprine and mercaptopurine.
3. Seek emergency medical help if you experience any of the side effects like muscle weakness, bladder pain, difficulty urination, etc.
4. It is recommended to avoid driving or using heavy machinery immediately after consuming this medicine.

Missed dose instructions:

Take this medicine as soon as you remember. However, if it is almost time for your next dose skip the dose and go back to your regular dosing schedule. Do not double dose to make up for the missed dose.

Overdose Instructions:

Seek emergency treatment or contact your physician in case if you experience any unusual signs and symptoms during the treatment with this medicine.

Storage Instructions:

• Store the medicine in a cool and dry place away from sunlight
• Keep away from the reach of children
• Discard the unused medicine safely after use

References:

1. What You Need to Know About Febuxostat [Internet]. Healthline. 2020 [cited 8 September 2020]. Available from: https://www.healthline.com/health/febuxostat-oral-tablet#side-effects

2. Febuxostat: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2020 [cited 8 September 2020]. Available from: https://medlineplus.gov/druginfo/meds/a609020.html

3. Febuxostat - DrugBank [Internet]. Drugbank.ca. 2020 [cited 8 September 2020]. Available from: https://www.drugbank.ca/drugs/DB04854

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Keep away from direct sunlight

Store in a dry place