CILAMIN 250 mg 10 Capsule

Prescription status:

Prescription required

Manufacturer Name: Panacea Biotec Ltd

Drug classification: Chelating agent

What is this used for: 

• Wilson's disease
• Rheumatoid arthritis
• Cystinuria 

When to not take this medicine:

• Hypersensitivity/Known Allergy towards Penicillamine
• Renal dysfunction
• Lupus erythematosus
• Aplastic anaemia 
• Severe thrombocytopenia.

How should i take the medicine:

Take this medicine with an adequate amount of water as directed by the physician. Do not take this medicine in small or larger amounts than recommended.

How this medicine works:

This medicine works by blocking the action of certain chemical messengers that are responsible for inflammation and slows the progress of the condition with certain joint diseases. It works in Wilson's disease by helping the body to remove excess copper.

Side effects

• Fever (Common)
• joint pain (Common)
• skin rash, hives, or itching (Common)
• swollen and/or painful glands (Common)
• ulcers, sores, or white spots on lips or in mouth (Common)
• Bloody or cloudy urine (Less Common)
• unusual bleeding or bruising (Less Common)
• unusual tiredness or weakness (Less Common)
• weight gain (Less Common)
• Abdominal or stomach pain (severe)
• blisters on skin (Rare)
• bloody or black, tarry stools (Rare)
• chest pain (Rare)
• coughing or hoarseness (Rare)
• dark urine (Rare)

Pregnancy warning: 

Category D; There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Lactation warning:

Use of this medicine is not recommended for lactating and breastfeeding mothers unless absolutely necessary. Inform your doctor about the use of this medicine. All the risks and benefits should be discussed with the doctor before taking this medicine.

Renal dose adjustments:

Care must be taken for individuals with kidney disease while taking this medicine. Please discuss appropriate dose adjustments with your doctor. Your doctor may also prescribe a suitable alternative on the basis of creatinine clearance values.

Hepatic dose adjustments:

Care must be taken for individuals with liver disease while taking this medicine. Please discuss appropriate dose adjustments with your doctor. Your doctor may also prescribe a suitable alternative.

Drug interactions:

• Clozapine-Major

Inform your doctor about the use of either medicine. Clozapine can lower white blood cell count, and combining it with other medications that can also affect bone marrow function such as penicillAMINE may increase the risk. You may be more likely to develop serious and potentially life-threatening infections as a result. Appropriate dose adjustments may be done, or suitable alternate medicine may be considered based on the condition.

• Calcium gluconate-Moderate

Inform your doctor about the use of either medicine. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of penicillAMINE into the bloodstream and reduce its effectiveness. You should take calcium gluconate at least 2 hours before or 2 hours after the penicillAMINE dose, penicillAMINE should be taken at least 2 hours before and not less than 6 hours after Suprep Bowel Prep. Appropriate dose adjustments may be done, or suitable alternate medicine may be considered based on the condition.

• Digoxin-Moderate

Inform your doctor about the use of either medicine. When these medicines are taken or used together it may decrease the effects of digoxin. Contact your doctor if your condition changes or if you experience worsening of your heart symptoms. Appropriate dose adjustments may be done, or suitable alternate medicine may be considered based on the condition.

• Leflunomide-Major

Inform your doctor about the use of either medicine. When these medicines are taken or used together can increase the risk of side effects that affect your bone marrow function, resulting in low numbers of different types of blood cells. This can make you more likely to develop anemia, bleeding problems, or infections. Appropriate dose adjustments may be done, or suitable alternate medicine may be considered based on the condition. 

Alcohol interactions:

Consumption of alcohol is not recommended while receiving/taking this medicine as it may cause interactions and lead to serious adverse effects and may worsen the health condition.

Food interactions:

 N/A.

Expert Advice:

1. This medicine should be taken on an empty stomach at least half an hour before meals 
2. Seek emergency medical help if you experience any of the side effects like Dizziness, Light-headedness, fainting, etc.
3. This medicine is to be taken at the same time of the day. Follow the missed dose instructions in case if you miss a dose.

Missed dose instructions:

Take this medicine as soon as you remember. However if it is almost the for your next dose skip the dose and go back to your regular dosing schedule. Do not double dose to make up for the missed dose.

Over dose Instructions:

Seek emergency treatment or contact your physician in case if you experience any unusual signs and symptoms during the treatment with this medicine.

Storage Instructions:

1.   Store the medicine in a cool and dry place away from sunlight

2.   Keep away from the reach of children

3.   Discard the unused medicine safely after use

References:

1. Medicines.org.uk. 2020. Penicillamine 250Mg Tablets - Summary Of Product Characteristics (Smpc) - (Emc). [online] Available at: <https://www.medicines.org.uk/emc/product/4069/smpc> [Accessed 15 December 2020].
2. Your Bibliography: Go.drugbank.com. 2020. Penicillamine | Drugbank Online. [online] Available at: <https://go.drugbank.com/drugs/DB00859> [Accessed 15 December 2020].

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Keep away from direct sunlight

Store in a dry place