Donep 10 mg 15 Tablets

Prescription status:

Prescription required   

Manufacturer Name: 

Alkem Laboratories Ltd

Drug classification: 

Cholinesterase inhibitors

What is this used for:

• Dementia 
• Alzheimer's disease
• Behavioural changes

When to not take this medicine:

• Hypersensitivity
• Stomach or duodenal ulcers 
• Have had seizures (fits) or convulsions  
• A heart condition (irregular or very slow heartbeat) 
• If you have or have had asthma or other long term lung disease
• If you have or have had liver problems or hepatitis  
• If you have or have had difficulty passing urine or mild kidney disease

How should i take the medicine:

Take this medicine with an adequate amount of water as directed by the physician. Do not take this medicine in small or larger amounts than recommended.

How this medicine works:

This medicine works by increasing the amount of a certain naturally occurring substance in the brain.

Side effects

• Diarrhoea  
• Feeling sick  
• Headaches 
• Muscle cramp  
• Tiredness  
• Difficulty in sleeping (insomnia)  
• Common cold  
• Loss of appetite  
• Hallucinations (seeing or hearing things that are not really there)  
• Unusual dreams including nightmares 
• Agitation  
• Aggressive behaviour  
• Fainting  
• Dizziness 
• Stomach feeling uncomfortable  
• Vomiting  
• Rash  
• Itching  
• Passing urine uncontrollably  
• Pain  

Pregnancy warning: Category C

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Lactation warning:

Use of this medicine is not recommended for lactating and breastfeeding mothers unless absolutely necessary. Inform your doctor about the use of this medicine. All the risks and benefits should be discussed with the doctor before taking this medicine.

Renal dose adjustments:

Care must be taken for individuals with kidney disease while taking this medicine. Please discuss appropriate dose adjustments with your doctor. Your doctor may also prescribe a suitable alternative on the basis of creatinine clearance values.

Hepatic dose adjustments:

Care must be taken for individuals with liver disease while taking this medicine. Please discuss appropriate dose adjustments with your doctor. Your doctor may also prescribe a suitable alternative.

Drug interactions:

• Amiodarone: Moderate

Inform your doctor about the use of either medicines. The use of these medicines are contraindicated since they may give serious adverse reactions which may lead to coma or death. Suitable alternatives may be considered based on the condition of the patient.

• Aspirin: Minor

Inform your doctor about the use of either medicines. The use of these medicines are contraindicated since they may give serious adverse reactions which may lead to coma or death. Suitable alternatives may be considered based on the condition of the patient.

• Diphenhydramine: Moderate

Inform your doctor about the use of either medicines. The use of these medicines are contraindicated since they may give serious adverse reactions which may lead to coma or death. Suitable alternatives may be considered based on the condition of the patient.

• Calcium: Unknown

Inform your doctor about the use of either medicines. The use of these medicines are contraindicated since they may give serious adverse reactions which may lead to coma or death. Suitable alternatives may be considered based on the condition of the patient.

• Diazepam: Unknown

Inform your doctor about the use of either medicines. The use of these medicines are contraindicated since they may give serious adverse reactions which may lead to coma or death. Suitable alternatives may be considered based on the condition of the patient.

• Ibuprofen: Minor

Inform your doctor about the use of either medicines. The use of these medicines are contraindicated since they may give serious adverse reactions which may lead to coma or death. Suitable alternatives may be considered based on the condition of the patient.

Alcohol interactions:

Consumption of alcohol is not recommended while receiving/taking this medicine as it may cause interactions and lead to serious adverse effects and may worsen the health condition.

Food interactions:  N/A.

Expert Advice: 

1. Food instruction: As directed by the doctor
2. This medicine can cause tiredness, dizziness and muscle cramp. If you experience any of these effects you must not drive or operate machinery.
3. This medicine is for use only in adult patients
4. Report any side effects like nausea, vomiting, etc.experienced immediately to the doctor.
5. This medicine contains lactose. If you are lactose intolerant then you must inform your doctor

Missed dose instructions:

Take this medicine as soon as you remember. However if it is almost the for your next dose skip the dose and go back to your regular dosing schedule. Do not double dose to make up for the missed dose.

Over dose Instructions:

Seek emergency treatment or contact your physician in case if you experience any unusual signs and symptoms during the treatment with this medicine.

Storage Instructions:

• Keep away from children
• Keep away from direct sunlight
• Store in cool and dry place
• Do not use after expiry

References:

1. Medicines.org.uk. 2020. [online] Available at: https://www.medicines.org.uk/emc/files/pil.6067.pdf [Accessed 17 November 2020].
2. Drugs, H., 2020. Donepezil: Medlineplus Drug Information. [online] Medlineplus.gov. Available at: https://medlineplus.gov/druginfo/meds/a697032.html#:~:text=Donepezil%20is%20in%20a%20class,occurring%20substance%20in%20the%20brain. [Accessed 17 November 2020].

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Keep away from direct sunlight

Store in a dry place