Zerodol P 100 mg/ 325 mg 10 Tablets

Prescription status:

Prescription required

Manufacturer Name: 

Ipca Laboratories Limited

Drug classification: 

Analgesic and anti pyretic combinations, NSAIDS

What is this used for:

• Fever
• Pain management
• Arthritic pain
• Ankylosing spondylitis

When to not take this medicine:

• Hypersensitivity/Known Allergy to this medicine combination
• Liver disease
• Kidney disease
• Metabolic acidosis 

How should I take the medicine?

Take this medicine with an adequate amount of water as directed by the physician. Do not take 

this medicine in small or larger amounts than recommended.

How this medicine works:

Aceclofenac works by blocking the natural enzymes which are responsible for the production of chemicals that cause the sensation of cause pain and inflammation at the site of trauma. Paracetamol works by elevating the pain threshold and regulating the blood flow across the skin resulting in heat loss and sweating.

Side effects 

• Anxiety (Less common)
• Gastrointestinal bleeding(Less common)
• Anemia(Less common)
• Kidney damage(Less common)
• Liver damage(Less common)
• Allergy(Less common)
• Thrombocytopenia(Less common)
• Skin rashes(Less common)
• Diarrhea(Less common)
• Black or tarry stools(Less common)
• Insomnia(Less common)
• Restlessness(Less common)
• Irritability(Less common)
• Nausea(Less common)
• Tachycardia (Less common)

Pregnancy warning: Not Assigned (Unknown)

Use of this medicine is not recommended for individuals who are pregnant or planning to become pregnant unless absolutely necessary as the safety and efficacy of this medicine is not well established. Inform your doctor about the use of either medicines. All the risks and benefits should be discussed with the doctor before taking this medicine.

Lactation warning:

Use of this medicine is not recommended for lactating and breastfeeding mothers unless absolutely necessary. Inform your doctor about the use of this medicine. All the risks and benefits should be discussed with the doctor before taking this medicine.

Renal dose adjustments:

Care must be taken for individuals with kidney disease while taking this medicine. Please discuss appropriate dose adjustments with your doctor. Your doctor may also prescribe a suitable alternative on the basis of creatinine clearance values.

Hepatic dose adjustments:

Care must be taken for individuals with liver disease while taking this medicine. Please discuss appropriate dose adjustments with your doctor. Your doctor may also prescribe a suitable alternative.

Drug interactions:

• Domperidone- Moderate 

Inform your doctor about the use of either medicines. Co-administration of domperidone along with this medicine may cause damage to the liver or kidneys. Suitable alternatives may be considered based on the condition of the patient.

• Procarbazine-Major

Inform your doctor about the use of either medicines. Co-administration of procarbazine along with this medicine may cause damage to the liver or kidneys. Suitable alternatives may be considered based on the condition of the patient.

• Selegiline- Major

Inform your doctor about the use of either medicines. Co-administration of selegiline along with this medicine may increase the effect of caffeine and may cause acute hypertensive episodes. Suitable alternatives may be considered based on the condition of the patient.

• Bupropion- Major

Inform your doctor about the use of either medicines. Co-administration of Bupropion along with this medicine combination may increase the levels of bupropion in blood and increase the chances of occurrence seizures. Suitable alternatives may be considered based on the condition of the patient.

• Digoxin- Moderate

Inform your doctor about the use of either medicines. Co-administration of this medicine combination along with digoxin may cause irregular heartbeats, etc. Suitable alternatives may be considered based on the condition of the patient.

• Aripiprazole- Moderate

Inform your doctor about the use of either medicines. Co-administration of this medicine combination along with aripiprazole may decrease the effectiveness of aripiprazole. Suitable alternatives may be considered based on the condition of the patient.

Alcohol interactions:

Consumption of alcohol is not recommended while taking this medicine as it may cause interactions and lead to serious adverse effects and may worsen the health condition.

Food interactions:

N/A

Expert Advice:

1. The use of this medicine is not recommended for individuals diagnosed with chronic alcoholism.
2. The use of this medicine is not recommended for individuals with kidney or liver diseases as this may cause organ failure or may cause severe health complications like coma or even death.
3. Discuss with the doctor about the risk associated with this medicine if taken during pregnancy or breastfeeding.

Missed dose instructions:

Take this medicine as soon as you remember. However, if it is almost the for your next dose skip the dose and go back to your regular dosing schedule. Do not double dose to make up for the missed dose.

Overdose Instructions:

Seek emergency treatment or contact your physician in case if you experience any unusual signs and symptoms during the treatment with this medicine.

Storage Instructions:

Store the medicine in a cool and dry place. Keep the medicine away from the reach of the children

References:

1. Aceclofenac 100 mg film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2020 [cited 29 September 2020]. Available from: https://www.medicines.org.uk/emc/product/4240/smpc#gref

2. Paracetamol Tablets 500mg (POM) - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2020 [cited 29 September 2020]. Available from: https://www.medicines.org.uk/emc/product/5916/smpc#gref

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Keep away from direct sunlight

Store in a dry place